Design of high avidity and low affinity antibodies for in situ control of antibody drug conjugate targeting

R. Evans, G.M. Thurber

Predictive Simulations in Preclinical Oncology to Guide the Translation of Biologics

S. Dong, I. Nessler, A. Kopp, B. Rubahamya, G.M. Thurber

Simulating the Selection of Resistant Cells with Bystander Killing and Antibody Coadministration in Heterogenous HER2

Menezes, B., J.L. Linderman, G.M. Thurber

Key metrics to expanding the pipeline of successful antibody-drug conjugates

Nessler, I., B. Menezes, G.M. Thurber

Reply: From mice to men: the exocrine pancreas does not matter for human GLP-1 receptor imagin

G.M. Thurber

Quantifying ADC bystander payload penetration with cellular resolution using pharmacodynamic mapping

Khera, E., C. Cilliers, M.D. Smith, M.L. Gana, K.C. Lai, T.A. Keating, A. Kopp, I. Nessler, A.O. Abu-Yousif, G.M. Thurber

Antibody Co-Administration Can Improve Systemic and Local Distribution of Antibody Drug Conjugates to Increase In Vivo Efficacy

Ponte, J., L. Lanieri, E. Khera, R. Laleau, O. Ab, C. Espelin, N. Kohli, B. Matin, Y. Setiady, M.L. Miller, T.A. Keating, R. Chari, J. Pinkas, R. Gregory, G.M. Thurber

Co-administered Antibody Improves Penetration of Antibody-Dye Conjugate into Human Cancers with Implicatio

Lu, G., N. Nishio, N. van den Berg, B. Martin, S. Fakurnejad, S. van Keulen, A. Dimitrios Colevas, G.M. Thurber, and E. Rosenthal

Optoacoustic imaging of GLP-1 Receptor with near-infared exendin-4 analog

Robers, S., E. Khera, C. Choi, T. Navaratna, J. Grimm, G.M. Thurber, and T. Reiner

Practical Guide for Quantification of In Vivo Degradation Rates for Therapeutic Proteins with Single-Cell Resol

Nessler, I., C. Cilliers, and G.M. Thurber

Increased Tumor Penetration of Single-Domain Antibody Drug Conjugates Impro

Nessler, I., E. Khera, S. Vance, A. Kopp, Q. Qiu, T.A. Keating, A. O. Abu Yousif. T. Sandal, J. Legg, L. Thompson, N. Goodwin, and G.M. Thurber

Directed Evolution Using Stabilized Bacterial Peptide Display

Navaratna, T., L. Atangcho, M. Mahajan, V. Subramanian, M. Case, A. Min, D. Tresnak, and G.M. Thurber

Severing Ties: Quantifying the Payload Release from Antibody Drug Conjugates

Kopp, A. and G.M. Thurber

An Agent-Based Systems Pharmacology Model of the Antibody Drug Conjugate Kadcyla to Predict Efficacy of Different D

Menezes, B.*, C. Cilliers*, T. Wessler, G.M. Thurber, and J. Linderman

Pharmacokinetic Considerations to Maximize an ADC’s Therapeutic Index

Thurber, G.M.

Antibody Coadministration as a Strategy to Overcome Binding-Site Barrier for ADCs: A Quantitative Investigation

Singh, A., L. Guo, A. Verma, G.Wong, G.M. Thurber, and D. Shah

Blocking Glucagon Like Peptide-1 Receptors in the Exocrine Pancreas Improves Specificity for Beta Cells in a Mouse

Khera, E., L. Zhang, S. Roberts, I. Nessler, D. Sandoval, T. Reiner, and G.M. Thurber.

Designing a disease screening pill: Challenges and opportunities in self-administration of optical probes

 Thurber, G.M. and R. Evans

Oral and Subcutaneous Administration of a Near-Infared Fluorescent Imaging Agent Detects Inflammation in a Mouse M

Bhatnagar, S.*, E. Khera*, J. Liao, V. Eniola, Y. Hu, D.E. Smith, and  G.M. Thurber

Hitting undruggable targets: viewing stabilized peptide development through the lens of quantitative systems pharm

Atangcho, L., T. Navaratna, and G.M. Thurber

Pharmacokinetic and immunological considerations for expanding the therapeutic window of next-gen

Khera, E., and G.M. Thurber

Tumor Drug Penetration Measurements Could Be the Neglected Piece of the Personalized Cancer Treatment Puzzle

Bartelink, I., E. Jones, S. Shahidi-Latham, E. P. Rong, Y. Zheng, P. Vicini, L. vant Veer, D. Wolf, A. Iagaru, D. Kroetz, B. Prideaux, C. Cilliers, G. Thurber, Z. Wimana, and G. Gebhart

"Standing by" for bystander effects: dual isotope imaging of Antibody-Drug Conjugates and payload distribu

Cilliers, C., and G.M. Thurber

Quantitative pharmacology in antibody-drug conjugate development: armed antibodies or targeted small mo

Nessler, I., E. Khera,and G.M. Thurber

Oral administration and detection of a near-infrared molecular imaging agent in an orthotopic mous

Bhatnagar, S., K. Dhingra Verma, Y. Hu, E. Khera, A. Priluck, D. Smith, and G.M. Thurber

Improved Tumor Penetration and Single-Cell Targeting of Antibody–Drug Conjugates Increases Anticancer Efficacy and Host Survival

Cilliers, C., B. Menezes, I. Nessler, J. Linderman, and G.M. Thurber

Computational transport analysis of antibody-drug conjugate bystander effects and payload t

Khera*, E., C. Cilliers*, S. Bhatnagar, and G.M Thurber

Ocular toxicity profile of ST-162 and ST-168 as novel bifunctional MEK/PI3K inhibitors

Smith, A., M. Pawar, M.E. Van Dort, S. Galbán, A.R. Welton, G.M. Thurber, B.D. Ross, and C.G. Besirli

Structure-guided design and initial studies of a bifunctional MEK/PI3K inhibitor (ST-168)

Van Dort, M.E., S. Galbán, C.A. Nino, H. Hong, A.A. Apfelbaum, G.D. Luker, G.M. Thurber, L. Atangcho, C.G. Besirli, and B.D. Ross

Tracking antibody distribution with near infrared fluorescent dyes: impact of dye structure and de

Cilliers, C., I. Nessler, N. Christodolu, and G.M. Thurber

Imaging in Diabetes

Zhang, L., and G.M. Thurber

A helix-stabilizing linker improves subcutaneous bioavailability of a helical peptide independent of

Zhang, L., T. Navaratna, and G.M. Thurber

Multiscale modeling of antibody-drug conjugates: connecting tissue and cellular distribution to w

Cilliers, C., H. Guo, J. Liao, N. Christodolu, and G.M. Thurber.

Mechanistic and quantitative insight into cell surface targeted molecular imaging agent design

Zhang, L.*, S. Bhatnagar*, E. Deschenes, and G.M. Thurber

Quantitative Impact of Plasma Clearance and Down-regulation on GLP-1 Receptor Molecular Imaging</

Zhang, L. and G.M. Thurber

Tumor Effect-Site Pharmacokinetics: Mechanisms and impact on efficacy

G.M. Thurber

Advances in measuring single-cell pharmacokinetics and pharmacology in vivo</

Vinegoni, C., J.M. Dubach, G.M. Thurber, M.A. Miller, R. Mazitschek, and R. Weissleder

Residualization rates of near infrared dyes for the rational design of molecular imaging agents</

Cilliers, C., J. Liao, L. Atangcho, and G.M. Thurber

A dual-purpose linker for alpha helix stabilization and imaging agent conjugation to glucagon-like Peptide-1 rece

Zhang, L., T. Navaratna, J. Liao, and G.M. Thurber

Population dynamics of islet-infiltrating cells in autoimmune diabetes

Magnuson, A.M, G.M. Thurber, R.H Kohler, R. Weissleder, D. Mathis, and C. Benoist

A systems pharmacology approach towards the design of inhaled formulations of rifampicin and isonia

Cilfone, N., E. Pienaar, G.M. Thurber, D. Kirschner, and J. Linderman

Multichannel imaging to quantify four classes of pharmacokinetic distribution

Bhatnagar, S., E. Deschenes, J. Liao, C. Cilliers, and G.M. Thurber

Effect of small molecule modification on single cell pharmacokinetics of PARP inhibitors

Thurber, G.M., T. Reiner, K.S. Yang, R.H. Kohler, and R. Weissleder

Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo

Thurber, G.M., K.S. Yang, T. Reiner, R.H. Kohler, P. Sorger, T. Mitchison, and R. Weissleder

A mechanistic compartmental model for antibody uptake in tumors

Thurber, G.M. and K.D. Wittrup

Noise suppressed, multifocus image fusion for enhanced intraoperative navigation

Feruglio, P.F., C. Vinegoni, L. Fexon, G.M. Thurber, A. Sbarbati, R. Weissleder

Efficient 18F-Labeling of Synthetic Exendin-4 Analogues for Imaging Beta Cells

Keliher, E.J., T. Reiner, G.M. Thurber, R. Upadhyay, R. Weissleder

Reactive Polymer Enables Efficient In Vivo Bioorthogonal Chemistry

Devaraj NK*, G.M. Thurber*, E.J. Keliher, B. Marinelli, R. Weissleder

Practical Theroretic Guidance for the Design of Tumor Targeting Agents

Wittrup K.D., G.M. Thurber, M.M. Schmidt, J.J. Rhoden

A Systems Approach for Tumor Pharmacokinetics

Thurber, G.M.*, R. Weissleder*

Accurate Measurement of Beta Cell Mass Using a Second-Generation Fluorescent Exendin-4 Analog

Reiner T., G.M. Thurber, J. Gaglia, et al.

Targeted Radionuclide Therapy, Chapter 12

Thurber G.M.

Quantitaing Antibody Uptake In Vivo: Conditional Dependence on Antigen Expression Levels

Thurber, G.M. and R. Weissleder

Detection Limits of Intraoperative Near Infared Imaging for Tumor Resection

Thurber, G.M., J.L. Figueiredo, R. Weissleder

Multicolor Fluorescent Intravital Live Microscopy (FILM) for Surgical Tumor Resection in a Mouse Xenograft Model

Thurber, G.M., J.L. Figueiredo and R. Weissleder

Hybrid in vivo FMT-CT imaging of protease activity in atherosclerosis with customized nanosensors</p

Nahrendorf, M., P. Waterman, G.M. Thurber, K. Groves, M. Rajopadhye, P. Panizzi, B Marinelli, E. Aikawa, M.J. Pittet, F.K. Swirski, and R. Weissleder

18F Labeled Nanoparticles for in vivo PET-CT Imaging

Devaraj, N.K., E.J. Keliher, G.M. Thurber, M. Nahrendorf, and R. Weissleder

Kinetics of Anti-Carcinoembryonic Antigen Antibody Internalization: Effects of Affinity, Bivalency, and Stability

Schmidt, M.M., G.M. Thurber, and K.D. Wittrup

Antibody tumor penetration: transport opposed by systemic and antigen-mediated clearance

Thurber, G.M., M.M. Schmidt, and K.D. Wittrup

Quantitative Spatiotemporal Analysis of Antibody Fragment Diffusion and Endocytic Consumption in Tumor Spher

Thurber, G.M. and K.D. Wittrup

Factors Determining Antibody Distribution in Tumors

Thurber, G.M., M.M. Schmidt, and K.D. Wittrup

Theoretic Criteria for Antibody Penetration into Solid Tumors and Micrometastases

Thurber, G.M., S.C. Zajic, and K.D. Wittrup

Cellular-Resolution Imaging of Bystander Payload Tissue Penetration from Antibody-Drug Conjugates

E. Khera, S. Dong, H. Huang, L. de Bever, F. van Delft, G. Thurber

Pharmacokinetics and Pharmacodynamics of TAK-164 Antibody Drug Conjugate Coadministered with Unconjugated Antibody

B. Menezes, E. Khera, M. Calopiz, M. Smith, M. Ganno, C. Cilliers, A. Abu-Yousif, J. Linderman, G. Thurber

Antibody–Drug Conjugate Sacituzumab Govitecan Drives Efficient Tissue Penetration and Rapid Intracellular Drug Release

A. Kopp, S. Hofsess, T. M. Cardillo, S. V. Govindan, J. Donnell, G. Thurber

Rapid Evaluation of Staple Placement in Stabilized ⍺ Helices Using Bacterial Surface Display

M. Case, T. Navaratna, J. Vinh. G. M. Thurber

Mechanistically weighted metric to predict in vivo antibody-receptor occupancy: An Analytical approach

E. Khera, J. Kim, A. Stein, M. Ratanapanichkich, G. M. Thurber

Improving Intracellular Delivery of an Antibody-Drug Conjugate Targeting Carcinoembry

I. Nessler, B. Rubahamya, A. Kopp, S. Hofsess, T. M. Cardillo, N. Sathyanarayan, J. Donnell, S. V. Govindan, G. M. Thurber

Generation of DAR1 Antibody-Drug Conjugates for Ultrapotent Payloads Using Tailored GlycoConnect Technology

L. de Bever, S. Popal, J. van Schaik, B. Rubahamya, F. van Delft, G. M. Thurber, S. van Berkel

Impact of tissue penetration and albumin binding on design of T cell targeted bispecific agents

A. Kopp, J. Kwon, C. Johnston, S. Vance, J. Legg, L. Galson-Holt, G. M. Thurber

Machine learning to predict continuous protein properties from binary cell sorting data and map unseen sequence space

M. Case, M. Smith, J. Vinh, G. M. Thurber

Optimizing solid tumor treatment with antibody-drug conjugates using agent-based modeling: considering the role of a carrier dose and payload class</a

M. Calopiz, J. J. Linderman, G. M. Thurber

Design of Crosslinking Antibodies For T-Cell Activation: Experimental and Computational Analysis of PD-1/CD137 Bispecific Agents

A. Kopp, J. Guan, C. Johnston, S. Vance, J. Legg, L. Galson-Holt, G. M. Thurber

Clinical translation of antibody drug conjugate dosing in solid tumors from preclinical mouse data

B. Rubahamya, S. Dong, G. M. Thurber

Maximizing activity and selectivity of antibody-mediated effector functions using antibody mixtures

T. Wang, A. Desai, G. M. Thurber, P. M. Tessier